Patrick C. Hines, MD, PhD

Patrick C. Hines, MD, PhD is an experienced pediatric critical care physician (general and cardiac) and a vascular biology research scientist. He is also the Founder and CEO of Functional Fluidics, a startup company developing clinical bioassays to measure blood function during simulated flow with microliters of whole blood. This technology is being adopted by pharmaceutical companies, clinicians, and research scientists to evaluate new therapies for red blood cell disorders such as sickle cell disease, coagulation disorders, and cancer. Dr. Hines was selected to the inaugural class of the Aspen Global Leadership Network’s Health Innovators Fellowship. He was the Chairman of the board of directors for the SNMA in the past. Areas of Interest: Role of beta-adrenergic stimulation in erythrocyte adhesion to the pulmonary vasculature; mechanisms of sickle erythrocyte adhesion

Representative Publications:

Central nervous system events in children with sickle cell disease presenting acutely with headache

TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1

Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions

Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion