Central nervous system events in children with sickle cell disease presenting acutely with headache | oneSCDvoice
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scientific articles

Central nervous system events in children with sickle cell disease presenting acutely with headache

key information

source: The Journal of Pediatrics

year: 2011

authors: Hines PC, McKnight TP, Seto W, Kwiatkowski JL

summary/abstract:

OBJECTIVE:
To determine the frequency of acute care visits and risk factors for central nervous system (CNS) events in children with homozygous sickle cell disease (SCD-SS) with an acute headache.
STUDY DESIGN:
This is a retrospective cohort study of acute care visits for headache in children with SCD-SS. The prevalence of headache visits, neuroimaging evaluation, and acute CNS events were calculated and clinical and laboratory variables assessed.
RESULTS:
Headache was the chief complaint in 102 of 2685 acute care visits (3.8%) by children with SCD-SS. Acute CNS events were detected in 6.9% of these visits. Neuroimaging was performed in 42.2% of visits, and acute CNS events were identified in 16.3% of studies. Factors associated with acute CNS events included older age, history of stroke, transient ischemic attack, or seizure, neurologic symptoms, focal neurologic exam findings, and elevated platelets.
CONCLUSIONS:
Acute headache is common in pediatric SCD-SS and more frequently associated with acute CNS events than in the general pediatric population. A history of stroke, transient ischemic attack, seizures, neurologic symptoms, focal neurologic exam, or elevated platelet counts at presentation warrant confirmatory imaging studies. Whether a more limited workup is adequate for other children should be confirmed in a larger, prospective study.

organisation: Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine

DOI: 10.1016/j.jpeds.2011.02.009

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