Google
Trusted Resources: People & Places
Healthcare providers, researchers, and advocates
Osheiza Abdulmalik, PhD
Researcher Research Associate II
Perelman School of Medicine
University of Pennsylvania
Rivella Lab
3615 Civic Center Blvd
Room 316B
Abramson Research Center
Philadelphia, Pennsylvania, United States
Dr. Abdulmalik’s research interests broadly encompass the hemoglobinopathies and red blood cell disorders, with particular focus on sickle cell disease and beta-thalassemia. Though both disorders are consequences of simple genetic mutations, the implications of these mutations are inherently complex, and include significant morbidities, lifelong challenges, reduced quality of life, and early mortality in patients; as well as substantial healthcare burden on families, caregivers, and society in general.
Dr. Abdulmalik’s current research focuses on three modalities of countering disease pathophysiology. The first approach, in tandem with a multidisciplinary team of collaborators, utilizes medicinal chemistry and structural biology to design novel drugs that block the primary pathophysiology of sickle cell disease, i.e., the polymerization of sickle hemoglobin.
Representative Publications:
Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation
+myBinderRelated Content
-
Opioid Abuse Backlash Could Hurt Sickle Cell Patients’ Medication Needs, Some FearWith drug overdoses now the leading caus...
-
Howard University Hospital Center for Sickle Cell DiseaseTransitioning from pediatric to adult pr...
-
Deepa G. Manwani, MDDr. Manwani completed her residency (199...
-
Sickle Cell Anemia Foundation of OregonThe Sickle Cell Anemia Foundation of Ore...
-
IASCNAPA Sickle Cell Disease Conference: Treating the Whole PersonDate: April 14-15, 2021 Place: Online/V...
-
Elyse Mandell, MSN, RNCSElyse Mandell is the Nurse Director and ...
-
Don’t Be Shy About Asking to Remain in the HospitalOne of the best feelings in the world is...
