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Sickle Cell Anemia with Splenic Sequestration
Sickle Cell Anemia with Splenic Sequestration: II. Epidemiology Most common in ages 1 to 4 years old III. Pathophysiology A. Splenic infarction typically occurs by Puberty in…
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Reference Materials · Complications/Clinical Manifestations · GI Complications · Splenic Sequestration
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Sickle Cell Anemia with Splenic Sequestration:
II. Epidemiology
Most common in ages 1 to 4 years old
III. Pathophysiology
A. Splenic infarction typically occurs by Puberty in patients with Hemoglobin SS
B. However, less severe forms of Sickle Cell Disease can occur in adulthood
IV. Precautions
Rapidly progressive course with significant risk of decompensation secondary to acute Anemia
V. Signs
A. Anemia
B. Abdominal Pain
C. Splenomegaly
1. Acute splenic enlargement (especially in under age 5 years, before auto-infarction)
2. Contrast with Sickle Cell Hemolytic Crisis in which the Spleen will be small or non-palpable
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