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Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Sickle Cell Anemia with Splenic Sequestration
source: Family Practice Notebook
year: 2018
summary/abstract:Sickle Cell Anemia with Splenic Sequestration:
II. Epidemiology
Most common in ages 1 to 4 years old
III. Pathophysiology
A. Splenic infarction typically occurs by Puberty in patients with Hemoglobin SS
B. However, less severe forms of Sickle Cell Disease can occur in adulthood
IV. Precautions
Rapidly progressive course with significant risk of decompensation secondary to acute Anemia
V. Signs
A. Anemia
B. Abdominal Pain
C. Splenomegaly
1. Acute splenic enlargement (especially in under age 5 years, before auto-infarction)
2. Contrast with Sickle Cell Hemolytic Crisis in which the Spleen will be small or non-palpable
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