The Management of Sickle Cell Disease | oneSCDvoice
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reference materials

The Management of Sickle Cell Disease

key information

source: National Institutes of Health

year: 1984


The demonstration in 1986 that prophylactic penicillin markedly reduces the incidence of pneumococcal sepsis (1) provided a powerful incentive for the widespread implementation of neonatal screening for sickle cell disease (SCD) (2). Neonatal screening, when linked to timely diagnostic testing, parental education, and comprehensive care, markedly reduces morbidity and mortality from SCD in infancy and early childhood (2-11). Approximately 2,000 infants with SCD are identified annually by U.S. neonatal screening programs (12,13). Screening also identifies infants with other hemoglobinopathies, hemoglobinopathy carriers, and in some states, infants with α-thalassemia syndromes.

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