The III & Long Foundation was founded by Santonio Holmes in the fall of 2011. The mission of the III & Long Foundation is to raise awareness to help fight Sickle Cell Disease (SCD) and provide financial support and treatment options for families affected by the disease. The III & Long Foundation works in partnership with local SCD organizations to provide grants that enable families to receive proper treatment and education.

The foundation is dedicated to building awareness about the disease through programs, merchandise, and fundraising events. These endeavors support families and raise funding for research on SCD.

III & Long Foundation produces special programs and educational services that unite and support the SCD community, including:
• Tutoring services for children during hospital treatment
• Educational seminars for parents
• Social media awareness campaign
• Thanksgiving and Christmas holiday community events
• Annual Strikes for Sickle Cell Bowling event