Google
Trusted Resources: People & Places
Healthcare providers, researchers, and advocates
Shengdar Q. Tsai, PhD
Researcher Assistant Member
Experimental Hematology Division
St. Jude Children’s Research Hospital
MS 341, Room D3022B
262 Danny Thomas Place
Memphis, Tennessee, United States
Dr. Shengdar Q. Tsai is an assistant member in the Department of Hematology at St. Jude Children’s Research Hospital. He obtained his B.S. in Biochemistry and Chemistry from the University of Michigan, M.S. in Bioinformatics and Ph.D. in Functional Genomics from North Carolina State University. He was a postdoctoral research fellow and instructor at Massachusetts General Hospital and Harvard Medical School. Dr. Tsai has focused on developing methods for high throughput genome editing with TALENs, and defining and improving the genome-wide specificity of CRISPR-Cas nucleases. His long-term research goals are to develop safe and highly specific targeted genome-editing strategies for treating human genetic diseases.
His research interests include:
• Improving genomic methods to define and measure gene editing “off-target” effects
• Protein engineering of CRISPR-Cas nucleases for precise gene correction
• Regulation of DNA damage repair choice between error-prone non-homologous end-joining and precise homology-directed repair
• Genome-scale CRISPR-Cas screening for novel effectors of hematological diseases
• Developing novel strategies for allele-specific editing of genetic mutations that cause sickle cell disease and other hematological disorders
+myBinderRelated Content
-
Sickle cell pain in the emergency departmentSickle cell disease is characterized by ...
-
Children’s MinnesotaChildren’s Cancer and Blood Disorders ...
-
Riley Hospital for Children at Indiana University HealthThe Cancer & Blood Diseases Departme...
-
Secondhand smoke is associated with more frequent hospitalizations in children with sickle cell diseaseTobacco smoke exposure has been associat...
-
Nirmish Shah, MDAs director of Duke’s sickle cell tran...
-
Tonya M. Palermo, PhDDr. Tonya Palermo is a professor of anes...
-
Global Blood Therapeutics Receives EMA PRIME Designation for GBT440 for the Treatment of Sickle Cell Disease (SCD)GBT440 is First Potential Treatment for ...
