Global Search

Trusted Resources: People & Places

Healthcare providers, researchers, and advocates

Back to People / Researchers
Shengdar Q. Tsai, PhD

Shengdar Q. Tsai, PhD

Researcher
Assistant Member
Experimental Hematology Division
St. Jude Children’s Research Hospital
MS 341, Room D3022B
262 Danny Thomas Place
Memphis, Tennessee, United States

Dr. Shengdar Q. Tsai is an assistant member in the Department of Hematology at St. Jude Children’s Research Hospital. He obtained his B.S. in Biochemistry and Chemistry from the University of Michigan, M.S. in Bioinformatics and Ph.D. in Functional Genomics from North Carolina State University. He was a postdoctoral research fellow and instructor at Massachusetts General Hospital and Harvard Medical School. Dr. Tsai has focused on developing methods for high throughput genome editing with TALENs, and defining and improving the genome-wide specificity of CRISPR-Cas nucleases. His long-term research goals are to develop safe and highly specific targeted genome-editing strategies for treating human genetic diseases.

His research interests include:
• Improving genomic methods to define and measure gene editing “off-target” effects
• Protein engineering of CRISPR-Cas nucleases for precise gene correction
• Regulation of DNA damage repair choice between error-prone non-homologous end-joining and precise homology-directed repair
• Genome-scale CRISPR-Cas screening for novel effectors of hematological diseases
• Developing novel strategies for allele-specific editing of genetic mutations that cause sickle cell disease and other hematological disorders

view profile

Related Content

Don’t forget to join the oneSCDvoice community!

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close

© 2022 rareLife solutions Inc.

Don’t forget to join the oneSCDvoice community!

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close