Enrico M. Novelli, MD

Dr. Novelli obtained his MD degree from the University of Milan, Italy in 1996. He was a postdoctoral fellow at Johns Hopkins University from 1996 to 1999 where he developed expertise in cellular biology and gene therapy. Dr. Novelli’s main areas of interest are sickle cell disease and disorders of hemostasis. Dr. Novelli holds a sickle cell disease and hemoglobinopathy clinic at the Hillman Cancer Center and a hemophilia and thrombosis clinic at the Hemophilia Center of Western Pennsylvania. In addition, he works as a member of the inpatient hematology consult service for several weeks of the year. Another longstanding interest of Dr. Novelli’s is in developing global health research and training initiatives in Tropical Hematology.

Research Interests: One recent interest of Dr. Novelli’s is elucidating the fundamental mechanisms underlying hemolysis-associated thrombosis and vascular dysfunction in SCD. Patients with SCD suffer from severe chronic hemolytic anemia and acute episodes of RBC trapping and destruction in the microvasculature (vaso-occlusive crises). Dr. Novelli’s current research project explores the role of Thrombospondin-1 (TSP1), a glycoprotein abundantly present in platelet α-granules which is emerging as a key regulator of hemostasis and thrombosis.

Representative Publications:

Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience

Pulmonary embolism in sickle cell disease: a case-control study

Crises in Sickle Cell Disease

The association of smartphone-based activity space measures with cognitive functioning and pain sickle cell disease

Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia

Can Neuroimaging Markers of Vascular Pathology Explain Cognitive Performance in Adults With Sickle Cell Anemia? A review of the Literature