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Environmental, genetic factors may predict longevity in sickle cell disease


A case series of individuals with sickle cell disease who lived into their ninth decade revealed potential genetic and environmental factors associated with their longevity.

The case report — published in Blood — included data from four women with sickle cell disease who have lived longer than age 80 years. Three women are American and received treatment at Thomas Jefferson University’s Sickle Cell Center. The fourth woman resided in Brazil.

One patient remained alive and in her 80s at the time of reporting. The remaining three patients are deceased and had lived into their 80s.

Although individuals with sickle cell disease are living longer than ever, most patients do not live beyond the age of 60 years, according to Samir K. Ballas, MD, FACP, emeritus professor of medicine and pediatrics at Thomas Jefferson University.

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