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scientific articles

Updated Mechanisms Underlying Sickle Cell Disease-Associated Pain

key information

source: Translational Perioperative and Pain Medicine

year: 2015

authors: Lutz B, Meiler SE, Bekker A, Tao YX


Sickle cell disease (SCD) is one of the most common severe genetic diseases around the world. A majority of SCD patients experience intense pain, leading to hospitalization, and poor quality of life. Opioids form the bedrock of pain management, but their long-term use is associated with severe side effects including hyperalgesia, tolerance and addiction.

Recently, excellent research has shown some new potential mechanisms that underlie SCD-associated pain. This review focused on how transient receptor potential vanilloid 1, endothelin-1/endothelin type A receptor, and cannabinoid receptors contributed to the pathophysiology of SCD-associated pain. Understanding these mechanisms may open a new avenue in managing SCD-associated pain and improving quality of life for SCD patients.

organization: The State University of New Jersey, USA; Georgia Regents University, USA

DOI: 10.1016/j.neulet.2019.134471

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