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reference materials

Transfusion Practices and Strategies for Individuals With Hemoglobin Disorders

key information

source: Georgia State University

summary/abstract:

Introduction

• Describe the optimal hemoglobin level when transfusing a sickle cell patient
• List common reasons for transfusing individuals with sickle cell disease
• Recognize common complications of transfusion in sickle cell disease
• Locate current evidence-based recommendations for transfusion in sickle cell disease

Case 1: Use of Transfusion during Acute Illness

• Recognize indications for red blood cell transfusion during acute illness in individuals with sickle cell disease
• Describe appropriate selection of blood products for transfusion during acute illness in individuals with SCD
• Identify management strategies for acute splenic sequestration in SCD
• Describe indications for RBC transfusion prior to elective surgical procedures in SCD

Case 2: Delayed Hemolytic Transfusion Reactions

• Describe practice recommendations for transfusion in sickle cell disease patients with acute chest syndrome
• Explain the pathophysiology of delayed hemolytic transfusion reactions and hyper hemolysis
• List techniques for evaluating alloantibodies and DHTR
• Explain the assessment and management of DHTR

Case 3: Management of Chronic Transfusion

• Describe the role of chronic transfusion in preventing and managing certain complications of sickle cell disease
• Describe prevention and management of alloimmunization in individuals on chronic transfusion
• Describe the importance of iron overload in chronically transfused patients with sickle cell disease
• Describe the management of iron overload in patients on chronic transfusion

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