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scientific articles

Endocrine and Growth Disorders in Children With Haemoglobin-SS

key information

source: African Journal of Health Sciences

year: 2020

authors: Moses Olayemi Akiibinu, Moses Olutola Omiwole, Franklin Akinola, Stephen Sijuola Akinola, Hawalat Mojisola Garuba, Toluwalope Yetunde Ogunmodede, Kikelomo Abibat Uzamot


Suboptimal growth and certain metabolic disorders are commonly presented by children with Sickle Cell Disease (SCD). SCD is an autosomal recessive genetic condition common in regions with intense malaria prevalence. The cycles of de-oxygenation and oxygenation of red blood cells producing repeated sickling and unsickling, leading to red cell damage is a concern.

There was need to establish the cause of common triggers for Vaso-Occlusive crises which include dehydration, infections, extreme temperature and emotional stress. Recurrent painful episodes, several physical and biochemical disorders including suboptimal growth, low immunity, anemia and a variety of serious organ system complications that cause life-long disabilities and/or early death in HbSS patients was a challenge. The highest frequencies (3 to 4% of populations) of Homozygous Sickle Cell disease occur in Sub-Saharan Africa.

The weight, height and BMI decreased significantly (p<0.05) in HbSS children compared with the controls. Plasma levels of GH, cortisol, TT3 and TT4 increased significantly (p<0.05) in HbSS-children compared with controls. Plasma levels of prolactin, TSH and insulin did not show significant (p>0.05) changes in the HbSS children compared with the controls. There was a significant (r=0.46, p=0.04) positive correlation between cortisol and GH in the children with HbSS. A negative correlation (r=-0.45, p=0.045) existed between TT4 and weight of HbSSchildren.

organization: Caleb University Lagos, Nigeria; Olabisi Onabanjo University Ago-Iwoye, Nigeria; Ladoke Akintola University of Technology, Nigeria

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