Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Prevalence and Correlates of Growth Failure in Young African Patients With Sickle Cell Disease
source: British Journal of Haematology
year: 2019
authors: Alexandre-Heymann L, Dubert M, Diallo DA, Diop S, Tolo A, Belinga S, Sanogo I, Diagne I, Wamba G, Boidy K, Ly ID, Kamara I, Traore Y, Offredo L, Jouven X, Ranque B
summary/abstract:Growth failure (GF) in children with sickle cell disease (SCD) tends to decline in high-income countries, but data are lacking in sub-Saharan Africa. We performed a cross-sectional study nested in the CADRE (Cœur, Artères et DREpanocytose) cohort in Mali, Senegal, Cameroon, Gabon and the Ivory Coast. SCD patients and healthy controls aged 5-21 years old were recruited (n = 2583). Frequency of GF, defined as a height, weight or body mass index below the 5th percentile on World health Organization growth charts, was calculated.
We assessed associations between GF and SCD phenotypic group, clinical and biological characteristics and history of SCD-related complications. GF was diagnosed in 51% of HbSS, 58% of HbSβ0 , 44% of HbSC, 38% of HbSβ+ patients and 32% of controls. GF in patients was positively associated with parents’ lower education level, male sex, age 12-14 years, lower blood pressure, HbSS or HbSβ0 phenotypes, icterus, lower haemoglobin level, higher leucocyte count and microalbuminuria. No association was found between GF and clinical SCD-related complications. In sub-Saharan Africa, GF is still frequent in children with SCD, especially in males and during adolescence. GF is associated with haemolysis and microalbuminuria, but not with the history of SCD-related clinical complications.
organization: Assistance Publique des Hôpitaux de Paris, France; Université Paris Descartes, France; Centre de Recherche et Lutte contre la Drépanocytose, Mali; Centre National de Transfusion Sanguine, Senegal; CHU de Yopougon, Ivory Coast; Centre Pasteur du Cameroun, Cameroon; CHU de Fann, Senegal; Centre Hospitalier d'Essos, CameroonDOI: 10.1111/bjh.15638
read more
+myBinderRelated Content
-
Sickle Cell Disease Can’t Stop Alliyahhttps://www.youtube.com/watch?v=pcFdP9cq...
-
The Teen Symposium: Engaging Adolescents and Young Adults With Sickle Cell Disease in Clinical Care and ResearchObjective: In the United States, sickle...
-
Realizing Effectiveness Across Continents With Hydroxyurea: Enrollment and Baseline Characteristics of the Multicent...Despite its well-described safety and ef...
-
The Truth About Chronic Illness in CollegeAs I write this post I am sitting in my ...
-
Our Healthcare System Abandons Adult Sickle Cell PatientsWhen Janoi Burgess was a child, he thoug...
-
Sickle Cell Awareness 365 Transition Focus GroupSickle Cell Awareness 365 Transition Fo...
-
Roald Dahl’s Marvellous Children’s Charity “Everyone’s Business” campaignhttps://www.youtube.com/watch?v=VqdP3Sxa...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.