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Stuart H. Orkin, MD
Researcher David G. Nathan Distinguished Professor of Pediatrics
Harvard Medical School
25 Shattuck Street
Boston, Massachusetts, United States
Dr. Orkin is David G. Nathan Distinguished Professor of Pediatrics at Harvard Medical School.
Dr. Orkin completed his medical graduation from Harvard Medical School in 1972, followed by postdoctoral research at the National Institutes of Health and clinical training in pediatrics and hematology-oncology at Children’s Hospital Boston and DFCI, where he joined the faculty in 1978. He is currently a Howard Hughes Medical Institute Investigator and was elected to the 2019-2020 Council of the National Academy of Medicine.
Over the past decade, his laboratory has defined critical nuclear regulators of hematopoiesis. His work on the molecular pathology of inherited blood disorders also greatly improved the diagnosis and treatment of these conditions. Stuart Orkin’s research focuses on stem cell biology, particularly the development and function of the blood system, the relationship between cancer and stem cells, and the mechanisms responsible for self-renewal of stem cells and the switch from fetal to adult hemoglobin.
Representative Publications:
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype
Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing
Medicine. Sickle cell disease at 100 years
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