Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Sickle Cell Anemia
source: Family Practice Notebook
year: 2020
summary/abstract:Sickle Cell Anemia:
II. Epidemiology
A. Sickle Cell Disease (Sickle Cell Anemia)
Prevalence (U.S.): 100,000 (1 per 365 black or african american descent)
B. Sickle Cell Trait (A/S) Incidence
1. Americans of African Descent: 1 in 12
2. Also Seen in Greeks, Italians, Turks, Saudi Arabians and hispanic patients
III. Pathophysiology
A. Normal Hemoglobin A replaced by Hemoglobin S (Hb S)
Deoxygenated Hemoglobin-S assumes a sickle shape
B. Substitution of Valine for glutamic acid
Occurs at the 6th position of the beta-chain
C. Mechanisms of dysfunction
1. Hypercoagulable
a. Round blood cells
b. Clotting Cascade activation
c. Inflammatory cascade activation
d. Platelet activation
Related Content
-
Sickle cell disease in childrenSickle cell disease (SCD) is an inherite...
-
MARAC Advisory Statement: Update About COVID-19December 23, 2021 – The Sickle Cell Di...
-
Sickle Options Video Libraryhttp://sickleoptions.org/en_US/video-lib...
-
Association among sickle cell trait, fitness, and cardiovascular risk factors in CARDIAThe contribution of sickle cell trait (S...
-
Sickle Cell Disease Management & Complications: Sophie Lanzkron MD of Johns HopkinsStuck on sickle cell disease? We hammer ...
-
Dr. Freda Gives the 411 on Sickle Cell Diseasehttps://www.youtube.com/watch?v=_aMrRu7R...
-
Sickle Cell Disease: After Years of Neglect Some Promise for SufferersIt’s Black History Month, when the nat...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.