Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Pregnancy outcome in patients with sickle cell disease in the UK–a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease
source: British Journal of Haematology
year: 2015
authors: Oteng-Ntim E, Ayensah B, Knight M, Howard J
summary/abstract:We describe the findings from a national study of maternal and fetal outcomes of pregnancy in women with sickle cell disease (SCD). Data were collected via the United Kingdom Obstetric Surveillance System between 1 February 2010 and 31 January 2011 from 109 women, of whom 51 (46·8%) had HbSS and 44 (40·4%) had HbSC. Data included antenatal, maternal and fetal outcomes. Comparisons were made between women with HbSS and HbSC. Incidence of complications were acute pain (57%), blood transfusion (26%), urinary tract infection (UTI; 12%) and critical care unit admission (23%) and these were all more common in women with HbSS than HbSC. There was no difference in the incidence of acute chest syndrome, hypertension and venous thromboembolism between HbSS and HbSC. Women with HbSS were more likely to deliver at <37 weeks gestation (P = 0·01) and their babies were more likely to have reduced birth weight. Delivery at <34 weeks was increased in both HbSS and HbSC women (5·9% vs. 4·6%) compared to national data. This study confirms a high rate of maternal and fetal complications in mothers with SCD, even in women with HbSC, which has previously been considered to have a more benign phenotype in pregnancy.
organization: King's College London; Guy's and St Thomas' Foundation Trust, LondonDOI: 10.1111/bjh.13270
read more full text
+myBinderRelated Content
-
Andrew L. (Larry) Frelinger, PhDDr. Frelinger is Assistant Professor of ...
-
Emmaus, a leader in sickle cell disease treatment, signs agreement with McKesson to expand distribution network for ...Emmaus Life Sciences, Inc., anno...
-
Optimizing Hydroxyurea Therapy for Sickle Cell AnemiaHydroxyurea has proven efficacy in numer...
-
Sickle Cell Disease Association of America, Inc., the Sickle Cell Foundation of Georgia, Inc., and the American Red ...The Sickle Cell Disease Associ...
-
Hassenfeld Children’s Hospital at NYU LangoneHassenfeld Children’s Hospital at NYU ...
-
Brandon Hardesty, MDBrandon Hardesty serves as an IHTC adult...
-
Coronavirus Preparedness for People With Chronic Diseases – WebinarEvent Date: Mar. 13, 2020 Event...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.