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Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Microparticles in sickle cell anaemia: promise and pitfalls
source: British Journal of Haematology
year: 2016
authors: Hebbel RP, Key NS
summary/abstract:Blood from patients with sickle cell disease contains microparticles (MP) derived from multiple cell sources, including red cells, platelets, monocytes and endothelial cells. MPs are of great interest because of their disease associations, their status as promising biomarkers, and the intercellular communications they mediate. To illustrate the likelihood of their relevance in sickle cell disease, we discuss the nature of MP, their profiling in sickle disease, some caveats relevant to their detection, their roles in supporting coagulation and the disparate influences they may exert upon the pathobiology of sickle cell disease.
organization: University of Minnesota Medical School, Minneapolis; University of North Carolina at Chapel HillDOI: 10.1111/bjh.14112
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