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Microparticles in sickle cell anaemia: promise and pitfalls

key information

source: British Journal of Haematology

year: 2016

authors: Hebbel RP, Key NS

summary/abstract:

Blood from patients with sickle cell disease contains microparticles (MP) derived from multiple cell sources, including red cells, platelets, monocytes and endothelial cells. MPs are of great interest because of their disease associations, their status as promising biomarkers, and the intercellular communications they mediate. To illustrate the likelihood of their relevance in sickle cell disease, we discuss the nature of MP, their profiling in sickle disease, some caveats relevant to their detection, their roles in supporting coagulation and the disparate influences they may exert upon the pathobiology of sickle cell disease.

organization: University of Minnesota Medical School, Minneapolis; University of North Carolina at Chapel Hill

DOI: 10.1111/bjh.14112

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