Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Management of Proliferative Sickle Cell Retinopathy
source: American Academy of Ophthalmology
authors: Mashal Akhter, Michelle W. Latting, Adrienne W. Scottsummary/abstract:
Proliferative sickle cell retinopathy (PSR) is a vision-threaten-ing complication of sickle cell disease (SCD). Ischemic events in the retina stimulate angiogenesis, resulting in retinal neovascularization.
SCD is caused by a mutation in the HBB gene, which encodes hemoglobin beta. PSR affects up to 40% of hetero¬zygous (HbSC) patients and 20% of homozygous (HbSS) patients. Although most patients remain visually asymptomatic, the incidence of visual loss among patients with HbSS and HbSC affected by PSR has been reported as 31 per 1,000 eyes compared with 1.4 per 1,000 in eyes with nonproliferative disease.
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