Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Emergency Medicine Management of Sickle Cell Disease Complications: An Evidence-Based Update
source: The Journal of Emergency Medicine
year: 2016
authors: Simon E, Long B, Koyfman A
summary/abstract:BACKGROUND:
Sickle cell disease (SCD) affects approximately 100,000 individuals in the United States. Due to alterations in the structural conformation of hemoglobin molecules under deoxygenated conditions, patients with SCD are predisposed to numerous sequelae, many of which require acute intervention.
OBJECTIVE:
Our aim was to provide emergency physicians with an evidence-based update regarding the diagnosis and management of SCD complications.
DISCUSSION:
SCD patients experience significant morbidity and mortality secondary to cerebrovascular accident, acute chest syndrome, acute vaso-occlusive pain crises, SCD-related multi-organ failure, cholecystitis, acute intrahepatic cholestasis, acute sickle hepatic crisis, acute hepatic sequestration, priapism, and renal disease. Emergency physicians must recognize acute manifestations of SCD in order to deliver timely management and determine patient disposition.
CONCLUSIONS:
A comprehensive review of the emergency department management of acute SCD complications is provided. Comprehensive understanding of these aspects of SCD can assist physicians in expediting patient evaluation and treatment, thus decreasing the morbidity and mortality associated with this hemoglobinopathy.
DOI: 10.1016/j.jemermed.2016.05.042
read more full text
Related Content
-
William Owen, MDDr. William Owen is a pediatric hematolo...
-
Safety of deep sedation in young children with sickle cell disease: a retrospective cohort studyOBJECTIVE: To assess the rates and type...
-
Potential Association between Sickle Trait and MRI-Defined Cerebrovascular Outcomes in Two Multi-Ethnic Elderly Popu...Sickle cell disease is a risk factor for...
-
Oxygen’s surprisingly complex journey through your body – Enda Butlerhttps://www.youtube.com/watch?v=GVU_zANt...
-
Children’s Hospital of MichiganThe Sickle Cell Center at the Children's...
-
Stephen Craig Nelson, MDDr. Stephen Nelson completed his Board C...
-
New Research Suggests SANGUINATE™ Reduces the Number of Sickled Red Blood Cells in Patients with Vaso-Occlusive Cr...SANGUINATE™, the only investigational ...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.