SCN was founded in 1995 after a group of stakeholders associated with the Sickle Cell Summer residential camps and other stakeholders in the Sickle Cell community met in response to feedback about the many challenges confronting Sickle Cell families surrounding health care, patient advocacy, and other related issues. The stakeholders agreed that a grassroots organization would both provide direct services to the Sickle Cell community and elevate Sickle Cell place in the national agenda.

Sickle Cell Community Health Network (SCCHN) helps individuals and families become actively involved in the health and wellness of themselves and their loved ones who are affected by the disease through community outreach, education, youth and family oriented programs. SCCHN is a primary resource for the Sickle Cell community for information and referral, support, and community building activities.