The Sickle Cell Foundation, Inc. was organized on February 21, 1980 at the office of the Tallahassee Urban League. Upon installation of the newly organized foundation, an official charter was issued and later received nonprofit organization 501(c)(3) exempt status. There are sixteen (16) chapters in the State of Florida. The Sickle Cell Foundation, Inc. is the only local agency serving District II providing services to the following counties: Leon, Jefferson, Wakulla, Madison, Taylor, Gadsden, and Jackson counties.

The mission of Sickle Cell Foundation, Inc. – Tallahassee is to enable individuals with sickle cell anemia to live lives to the extent possible unhampered and uncompromised by their sickle cell conditions and to increase the knowledge and understanding of sickle cell disease as a health problem through professional standards of administration, health care, public relations and fundraising.