Africa Sickle Cell Alliance was founded as a result of the Amplify Sickle Cell Voices Series. An initiative which started as a result of people coming from different parts of the world to discuss issues affecting the sickle cell community. Africa Sickle Cell Alliance is a group of African Sickle Cell Organisations representing patients, caregivers and all stakeholders advancing the rights of those affected by sickle cell disease. It is an umbrella organisation representing all organisations in Africa with currently over 23 African Countries as members.

Africa Sickle Cell Alliance is tasked with the responsibility of advocacy, research and development of sickle cell, public education and awareness of sickle cell, social and family support of people living with sickle cell and partnerships with public and private sectors in the development of sickle cell treatment, care, and policies in Africa.