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Elizabeth S. Klings, MD

Director, Center for Excellence in Sickle Cell Disease
Boston University School of Medicine
Shapiro Building, Suite 9B
Boston, Massachusetts, United States

Dr. Klings is an Associate Professor in the Department of Medicine. She attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center. Additionally, she has a clinic in the Pulmonary Hypertension Center at Boston Medical Center where she is involved in the diagnosis, evaluation and treatment of patients with pulmonary hypertension (Pulmonary Hypertension Center). She has special interest in the management of patients with chronic dyspnea and is the former Medical Director of the Pulmonary Rehabilitation Program.

Dr. Klings has clinically phenotyped over 200 adults with sickle cell disease being treated at Boston Medical Center and has utilized genomic and proteomic approaches to understand the pathogenesis for pulmonary vascular disease in this population.

Her current research interests surround understanding the role of sleep-disordered breathing, chronic intermittent hypoxia and thrombosis as pulmonary vascular modulators in sickle cell disease.


Special Interests:


– Pulmonary complications of sickle cell disease

– Role of genetic modulation in pulmonary hypertension of sickle cell disease



– Pulmonary Hypertension

– Pulmonary Complications of Sickle Cell Disease

– Critical Care Medicine

– Pulmonary Rehabilitation


Representative Publications:

Prostacyclin-analog therapy in sickle cell pulmonary hypertension

Chronic Pulmonary Complications of Sickle Cell Disease

Clinical and Laboratory Findings Associated with Sleep Disordered Breathing in Sickle Cell Disease

Sickle cell disease: wheeze or asthma?

Management of patients with sickle cell disease