Dana Carroll, PhD, is a distinguished professor in the Department of Biochemistry at the University of Utah School of Medicine and a member of the Nuclear Control of Cell Growth and Differentiation Program at the Huntsman Cancer Institute. Carroll’s research involves making specific changes in chromosomal DNA using targetable nucleases. His lab pioneered the development of zinc-finger nucleases as gene targeting tools, and they have continued working with the more recent TALENs and CRISPR/Cas nucleases. Much of the effort has been focused on optimizing the efficiency of these reagents for targeted mutagenesis and gene replacement, which could ultimately provide treatment for many diseases, including sickle cell disease. This technology has now been applied to more than 40 different organisms, including current clinical trials in humans.

Representative Publications:

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

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