Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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The scientist thinking past the breakthrough
In the tribal communities of Odisha and the plains of Gujarat, a disease has traveled quietly through bloodlines for centuries, unannounced and largely unaddressed. Sickle cell…
Doctors flag removal of thalassemia from Centre's child health programme
Doctors with Disabilities has urged J P Nadda to restore thalassemia and sickle cell screening in RBSK 2.0. They say the exclusion weakens early diagnosis and clashes with…
Frailty phenotype in adults with sickle cell disease
Abstract Background: People with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related stressors. Frailty…
Sustainment of Hydroxyurea Adherence in Patients With Sickle Cell Disease
Key Points Question Do hydroxyurea use (ie, taking the medication at all) and adherence (ie, days taken per week) change over time, and are they associated with patient…
Genetic, clinical, and biological risk factors associated with optic nerve thinning in sickle cell disease
Objectives To determine whether adults with sickle cell disease (SCD) without glaucoma exhibit subclinical structural optic neuropathy (SON) on optical coherence tomography (OCT)…
Sickle cell disease after Casgevy: seven companies to watch in 2026
Casgevy’s approval changed the sickle cell disease landscape. Developed by Vertex Pharmaceuticals and CRISPR Therapeutics, the therapy showed that the disease could be tackled at…
Johns Hopkins physicians achieve 95% cure rate for sickle cell disease with bone marrow transplant
A reduced-intensity bone marrow transplant regimen developed by Johns Hopkins physicians provides durable engraftment with low rejection rates and also may preserve fertility…
Understanding Sickle Cell Disease Endothelial Pathology Through the Lens of Liver Sinusoidal Endothelial Cells
What are the main findings? Endothelial dysfunction is a hallmark of sickle cell disease (SCD), which is associated with both acute and chronic crises in patients. Whereas lung or…
New York study finds regional gaps in sickle cell disease hospitalizations
Sickle cell disease (SCD) hospitalization patterns vary across New York State, with New York City showing the largest share of hospitalizations and Long Island reporting the…
How scientists made the discoveries behind a game-changing gene therapy for sickle cell disease
Sickle cell disease is the scourge of a person’s red blood cells. The inherited blood disorder, which disproportionately affects people in sub-Saharan Africa and India, can cause…
Sickle Cell Hospitalizations Are Getting More Severe—And Where Patients Live Matters
Data from a large New York State analysis found that sickle cell disease hospitalizations are becoming more severe over time, with significant regional disparities in outcomes…
Novel use of a hash-based tokenization for sharing sickle cell disease data without sharing protected health information
Key Points This is the first SCD project to implement a privacy-preserving technique for linking individuals across multiple registries. Linkage of multiple registries enables…