Clinical Trials and Research1 min read
Understanding Sickle Cell Disease Endothelial Pathology Through the Lens of Liver Sinusoidal Endothelial Cells
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What are the main findings?
- Endothelial dysfunction is a hallmark of sickle cell disease (SCD), which is associated with both acute and chronic crises in patients.
- Whereas lung or kidney endothelial beds are widely studied in SCD, liver sinusoidal endothelial cells are recently gaining attention for their previously unrecognized roles. This review discusses the function and regulation of LSECs in SCD.
What is the implication of the main finding?
- Understanding the molecular processes of LSEC-driven hemoglobin clearance and senescence may identify new biomarkers and regulators of acute and chronic liver damage in SCD.
- Modulations of LSECs scavenging activities may emerge as a potential therapeutic option for liver damage associated with SCD.