Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Sickle Cell Anemia
source: Family Practice Notebook
year: 2020
summary/abstract:Sickle Cell Anemia:
II. Epidemiology
A. Sickle Cell Disease (Sickle Cell Anemia)
Prevalence (U.S.): 100,000 (1 per 365 black or african american descent)
B. Sickle Cell Trait (A/S) Incidence
1. Americans of African Descent: 1 in 12
2. Also Seen in Greeks, Italians, Turks, Saudi Arabians and hispanic patients
III. Pathophysiology
A. Normal Hemoglobin A replaced by Hemoglobin S (Hb S)
Deoxygenated Hemoglobin-S assumes a sickle shape
B. Substitution of Valine for glutamic acid
Occurs at the 6th position of the beta-chain
C. Mechanisms of dysfunction
1. Hypercoagulable
a. Round blood cells
b. Clotting Cascade activation
c. Inflammatory cascade activation
d. Platelet activation
Related Content
-
Sisterly bond behind sickle-cell curehttps://www.youtube.com/watch?v=9S-xVGsR...
-
New Jersey may start a confidential sickle cell trait registryThe New Jersey Legislature is considerin...
-
Possible Cure for Sickle Cell Found in ParisHematologists, sickle cell patients, and...
-
Sickle cell trait and cognitive function in African Americans: The reasons for geographic and racial differences in ...Sickle cell anaemia (SCA) has been assoc...
-
Maternal/Perinatal Outcome in Women With Sickle Cell Disease: A Comparison of Two Time PeriodsObjective: To compare pregnancy outcome...
-
Sickle Cell Disease Association of America, Inc. Awards Community Based Organizations With $2,033,080 for Newborn Sc...The Sickle Cell Disease Association of A...
-
Indiana Sickle Cell Conference 2020 – VirtualThis one-day conference will provide hel...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.