• Join Today!

Become a member and connect with:

  • An Active Online Community
  • Articles and Advice on SCD
  • Help Understanding Clinical Trials
abstracts & posters

A randomized controlled trial of home-based computerized working memory training for children with sickle cell disease

key information

source: The American Society of Pediatric Hematology/Oncology Conference

year: 2018

authors: Steven J. Hardy, Sarah Bills, Shane Wise, Emily R. Meier, Jeffrey C. Schatz, Kristina Hardy



To determine the effects of Cogmed, a home-based computerized Working Memory (WM) training intervention, in children with SCD using a randomized controlled trial design.



Ninety-one participants (M age=10.43, SD=2.93; 59% female; 69% HbSS) enrolled in the study; 52% (n=47) exhibited WM deficits and were randomized to either begin Cogmed immediately or wait 5-8 weeks before starting Cogmed. Among those that have received the intervention and reached the end of their training period (n=42), 27 participants (59%) completed at least 5 Cogmed sessions, 19 (41%) finished at least 10 sessions, and 7 finished at least 20 sessions (15%). The mean number of completed Cogmed sessions was 9.10 (SD=7.77).

Paired Samples t-tests revealed significant improvements on the Working Memory Index (t[38]=-2.44, p=0.020) and on the Digit Span (t[40]=-3.02, p=0.004), and Spatial Span-Backward (t[39]=-2.83, p=0.007) subtests. Improvements were especially pronounced for participants completing at least 10 sessions. Partial correlations controlling for respective baseline scores indicated that the number of Cogmed sessions completed was positively correlated with post-test scores on Digit Span (r=.38, p=.017) and Spatial Span-Backward (r=0.45, p=0.004) subtests. Among participants who completed at least 10 Cogmed sessions, 77% scored in the Average range or higher on the Working Memory Index at the post-intervention assessment, compared to 58% at baseline.



Results support the efficacy of Cogmed in producing significant improvements in WM. A dose-effect was observed such that participants who completed more Cogmed sessions had greater improvements in WM. Home-based cognitive training programs may ameliorate SCD-related WM deficits but methods for motivating and supporting patients as they complete home-based interventions are needed to enhance adherence and effectiveness.


read more

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.