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scientific articles

Nutcracker Syndrome and Sickle Cell Trait: A Perfect Storm for Hematuria

key information

source: Journal of General Internal Medicine

year: 2017

authors: Ahmad A, McElwee SK, Kraemer RR


We describe the case of a 27-year-old woman with a history of sickle cell trait (SCT) who presented with several months of hematuria and was found to have nutcracker syndrome (NCS). While SCT is a common cause of hematuria resulting from renal papillary necrosis, our patient had concomitant abdominal pain and anemia, prompting further evaluation and the subsequent diagnosis of NCS. Interestingly, the anoxia in the left renal vein from NCS predisposes patients with SCT to sickling. Our case highlights key clinical features of both NCS and SCT and the relationship between the two disease processes.

organization: University of Alabama at Birmingham; Birmingham Veterans Affairs Medical Center

DOI: 10.1007/s11606-017-4008-z

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