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scientific articles

Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

key information

source: British Journal of Haematology

year: 2016

authors: Nielsen L, Canouï-Poitrine F, Jais JP, Dahmane D, Bartolucci P, Bentaarit B, Gellen-Dautremer J, Remy P, Kofman T, Matignon M, Suberbielle C, Jacquelinet C, Wagner-Ballon O, Sahali D, Lang P, Damy T, Galactéros F, Grimbert P, Habibi A, Audard V


We performed a retrospective study to assess the changes in clinical, biological and heart echocardiographic parameters in 32 sickle cell disease (SCD) patients beginning haemodialysis. Acute SCD-related complications were similar at 6 months before and 6 months after the initiation of haemodialysis. Median haemoglobin level did not change significantly, but the need for blood transfusions increased (P < 0·001). The 5-year incidence of death was higher in SCD patients (P < 0·0001). The 5-year likelihood of receiving a renal graft was lower in SCD patients (P = 0·022). Our findings suggest that SCD patients have poorer survival and a lower likelihood of receiving a renal graft.

organization: Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Créteil, France; Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunity-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Créteil, France; Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Santé Publique, Créteil, France; UPEC, DHU A-TVB (Aging-Thorax-Vessels-Blood), IMRB, EA 4393 CEpiA (Clinical Epidemiology And Ageing Unit), Créteil, France; Université Paris Descartes; Hôpital Necker Enfants Malades, Biostatistics & Ile de France REIN Registry Epidemiologic Units, Paris, France; Centre de Référence des Syndromes Drépanocytaires Majeurs, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France; Laboratoire Régional d'Histocompatibilité, Hôpital Saint-Louis, Paris, France; Direction Générale Médicale et Scientifique, Agence de la Biomédecine, Saint Denis, France; Centre de Recherches en Épidémiologie et Santé des Populations, Villejuif, France; Groupe de Recherche Clinique (GRC) Amyloid Research Insitute, Créteil, France

DOI: 10.1111/bjh.14040

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