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scientific articles

Genitourinary manifestations of sickle cell disease

key information

source: Cleveland Clinic Journal of Medicine

year: 2015

authors: Gebreselassie S, Simmons MN, Montague DK


Sickle cell disease is a common genetic disorder characterized by sickling of red blood cells under conditions of reduced oxygen tension. In turn, sickling leads to intravascular hemolysis and vaso-occlusive events with subsequent tissue ischemia-reperfusion injury affecting multiple organs, including the genitourinary system. Our review of the genitourinary manifestations of sickle cell disease focuses on sickle cell nephropathy, priapism, and other genitourinary complications such as papillary necrosis and renal medullary carcinoma.

organization: Cleveland Clinic Florida; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland; Glickman Urological and Kidney Institute, Cleveland; American Urological Association,USA

DOI: 10.3949/ccjm.82a.14029

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