Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Spectral domain optical coherence tomography in patients with sickle cell disease
source: The British Journal of Ophthalmology
authors: Mathew R, Bafiq R, Ramu J, Pearce E, Richardson M, Drasar E, Thein SL, Sivaprasad Ssummary/abstract:
To evaluate spectral domain optical coherence tomography (SD-OCT) changes in central retina and choroid in patients with sickle cell disease (SCD).
Data on visual acuity, severity of sickle cell retinopathy, macular volume scans and choroidal thickness on SD-OCT were analysed from 208 eyes of 107 consecutive patients referred for screening for SCD. The retinal and choroidal thickness of eyes with SCD were also compared with age and ethnicity matched controls.
44% of the eyes of patients with SCD showed discrete areas of retinal thinning in the temporal macular area. Proliferative sickle cell retinopathy was more prevalent in these eyes compared with SCD eyes with normal macular morphology (67% vs. 48%; p=0.0017). The temporal total and inner retinal thickness, macular volume and choroidal thickness were significantly lower in patients with SCD compared with age, gender and ethnicity matched controls. Macular splaying (widening of the macular contour) was noted in 30% of eyes in both groups. The choroidal and retinal thickness values showed good intergrader reliability using weighted κ statistics (0.550-0.9).
Quantitative and qualitative changes on SD-OCT are present in asymptomatic SCD eyes. Proliferative retinopathy is more prevalent in eyes with discrete areas of macular thinning.organization: King's College Hospital NHS Foundation Trust, London; King's College London; James Black Centre, London; UK NIHR Moorfields Biomedical Research Centre
read more full text
Sickle Cell Disease: Splenic SequestrationSplenic sequestration is a problem with ...
The role of blood rheology in sickle cell diseaseStudies performed in the last decades ha...
Quest Diagnostics Launches Genetic Test to Assess Risk for Sickle Cell Anemia, Other Inherited DisordersCouples who wish to know the risk of pas...
Sickle Cell Retinopathyhttps://www.youtube.com/watch?v=tCgAHWvV...
SCA Therapy Hydroxyurea Doesn’t Boost Malaria Risk in Sub-Saharan Africa, Study FindsHydroxyurea, a treatment recommended for...
Patient Perspective: The Journey of Pain in Sickle Cell Diseasehttps://www.youtube.com/watch?v=F4raFO0e...
Grant Recipient Uses Mobile Device Observation in Sickle Cell Pain StudyTechnology takes center stage in a new...
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.