Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Sickle Cell Anemia
source: Orphanet
year: 2021
summary/abstract:Epidemiology:
Sickle cell anemia (SCA) is the most common form of SCD. Worldwide, it is estimated that there are over 400,000 newborns with sickle cell anemia. The birth prevalence varies according to region, with prevalence greatest in regions affected by holoendemic malaria. In Europe, the pooled birth prevalence is 1/2,300, although this varies between countries.
Clinical Description:
The disease does not manifest during fetal life or up to the first three months of life due to the presence of high levels of fetal hemoglobin. Clinical manifestations evolve with age and are extremely variable between individuals and at different times. In addition to anemia and bacterial infections, VOAs cause hyperalgic focal ischemia (and sometimes infarction) when they occur in the abdomen, chest or skeleton. Over the course of time, VOAs may compromise the integrity of tissues or organs.
read more
Related Content
-
Genetics of sickle cell diseaseSickle cell disease is inherited from pa...
-
Acute Care Utilization in Pediatric Sickle Cell Disease and Sickle Cell Trait in the USA: Prevalence, Temporal Trend...The objective of this study was to analy...
-
MARAC Advisory Statement: COVID-19 UpdateAugust 26, 2021 — The Sickle Cell Dise...
-
Cardinals’ Bruce Arians: WR John Brown carries sickle-cell traitA blood test Thursday revealed that Ariz...
-
6th Annual Chicago Sickle Cell SummitDate & Time Sep 28, 2023 11:00 AM...
-
The Ways I Made Hydration a HabitWhen I was younger and didn’t have a f...
-
Darryl Watkins Stays Positive in Spite of Sickle Cell DiseaseDarryl Watkins has the HbSS variant of s...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.