Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience
source: British Journal of Haematology
year: 2017
authors: Makubi A, Mmbando BP, Novelli EM, Lwakatare J, Soka D, Marik H, Tibarazwa K, Ngaeje M, Newton CR, Gladwin MT, Makani J
summary/abstract:Data on the magnitude and risk factors for hypertension in sickle cell anaemia (SCA) are limited. A retrospective analysis of individuals with SCA aged >=15 years enrolled from 2004-2014 at Muhimbili National Hospital, Tanzania was conducted to determine the prevalence, incidence and risk factors for hypertension. A total of 1013 individuals with SCA were analysed, of whom 571(56%) were females. The median age [interquartile range] was 17 [15-22] years. Four hundred and forty-one (44%) of the patients had relative hypertension [systolic blood pressure (SBP) 120-139 mmHg or diastolic blood pressure (DBP) 70-89 mmHg], and 79 (8%) had hypertension (SBP >= 140 mmHg or DBP >= 90 mmHg). The incidence of hypertension was 64/1000 person years of observation and the 5-year survival rate was 0·71 [95% confidence interval (CI): 0·67-0·75]. In multivariate analysis, age>18 years, Hazard ratio (HR) 1·50 (95% CI: 1·03-2·18); pulse pressure, HR 0·64 (95% CI: 0·42 to 0·98); pulse rate, 1·02 (95% CI: 1·01-1·03); body mass index (BMI), HR 1·08 (95% CI: 1·03-1·13); blood transfusion, HR 2·50 (95% CI: 1·01-6·21) and haemoglobin, HR 1·12 (95% CI: 1·05-1·33) were independently associated with hypertension. In conclusion, despite the younger age, hypertension in this population was higher than that reported in others studies. Age, BMI, pulse pressure and haemoglobin were independently associated with hypertension in SCA.
organization: Muhimbili University of Health and Allied Sciences, Dar es Salaam; Muhimbili Wellcome Programme, Dar es Salaam; National Institute of Medical Research, Tanga; University of Pittsburgh; Jakaya Kikwete Cardiac Institute, Dar es Salaam; University of Oxford, LondonDOI: 10.1111/bjh.14330
read more full text
Related Content
-
Stress and Mental Health in SCD Interview Clipshttps://www.youtube.com/watch?v=LCcSTC-X...
-
Metabolic syndrome among adults living with sickle cell diseaseMetabolic syndrome (MetS) is a key risk ...
-
Hypersensitivity to Allergens May Increase Risk of Acute Chest Syndrome in Sickle Cell Anemia ChildrenHypersensitivity to allergens in childre...
-
Increased prevalence of type 2 diabetes-related complications in combined type 2 diabetes and sickle cell traitObjective: The prevalence of type 2 dia...
-
Swee Lay Thein, MB, BS, FRCP, FRCPath, DSSwee Lay Thein is the Chief of the Sickl...
-
Montefiore Medical CenterAt the Division of Hematology at Montefi...
-
Sickle Cell Disease Association of America, Inc. and Hemanext® Inc. Form New Strategic PartnershipSickle Cell Disease Association of Ameri...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.