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Progressive Loss of Brain Volume in Children with Sickle Cell Anemia: A Report from the Silent Cerebral Infarct Transfusion Trial Cohort
source: American Society of Hematology
year: 2015
authors: Odianosen Eigbire-Molen, Deepika S. Darbari, Maria R. Ponisio, Mikhail V. Milchenko, Mark J. Rodeghier, James F. Casella, Robert McKinstry, Michael R. DeBaun
summary/abstract:Introduction: Neurological injury is a common complication of sickle cell anemia (SCA). SCA is the most common cause of stroke in children between 1-14 years of age, while silent cerebral infarct is the most common neurologic injury in this population. Young children are particularly vulnerable to the adverse impact of strokes, and are at risk of cognitive and developmental deficits; thus, we sought to examine brain volume changes in children with SCA.
The Silent Cerebral Infarct Transfusion (SIT) Trial was a multicenter trial designed to determine the efficacy of blood transfusion therapy for prevention of recurrent silent cerebral infarcts in participants with SCA. This intervention trial followed 196 children with SCA aged 5-14 years randomized to receive blood transfusion therapy or observation for 36 months (DeBaun et al. N Engl J Med. 2014; 371(8):699-710). As a planned secondary analysis, we used the SIT Trial brain imaging archive to determine longitudinal brain volume change in children with SCA. We performed a multivariable analysis using demographic and clinical variables to identify predictors of brain volume change.
organization: Georgetown University School of Medicine, Washington, DC; Children's National Medical Center, Washington, DC; Washington University in St. Louis, School of Medicine; Rodeghier Consultants, Chicago; Johns Hopkins University School of Medicine, Baltimore; Vanderbilt University School of Medicine, Nashvilleread more
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