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Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology
source: Blood
year: 2016
authors: Zhang D, Xu C, Manwani D, Frenette PS
summary/abstract:Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative. Specific treatment targeting major complications such as vaso-occlusion is still lacking. Recent studies have identified various cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we review the role of these elements and discuss the opportunities for therapeutic intervention.
organization: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research,Albert Einstein College of Medicine, Bronx, NYDOI: 10.1182/blood-2015-09-618538
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