Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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Treatment of Sickle Cell Anemia: Pharmacological, Transfusion, and Genetic Strategies
Sickle cell disease (SCD) is a prevalent hereditary hemoglobinopathy characterized by hemoglobin S (HbS) polymerization, resulting in chronic hemolysis, vaso-occlusion, and…
Plasma proteome signatures are predictive of mortality in sickle cell disease
Sickle cell disease (SCD) is associated with severe systemic complications and increased mortality risk. Predicting SCD severity is currently difficult because of a lack of…
CS-206 in Patients With Sickle Cell Disease
Overview The goal of this open label, single-arm clinical study is to learn about the safety and efficacy of CS-101 injection in treating sickle cell disease. Description CS-101…
Exploring the impact of haptoglobin gene polymorphisms and severity of sickle cell disease: meta-analysis and gene set enrichment study
Abstract Background: Sickle cell disease, a genetic blood disorder marked by vaso-occlusive crises and severe pain, presents a major global health challenge. Haptoglobin, a…
Tessera Therapeutics Showcases New Preclinical Data Advancing In Vivo Program in Sickle Cell Disease and CAR-T Applications at the American Society of Gene and Cell Therapy 29th Annual Meeting
Presented improved editing data in non-human primates (NHP) for sickle cell disease (SCD), demonstrating a single dose of Gene Writer achieved an average of 85% of long-term…
Rise in sickle cell disease prompts NHS call for more Black blood donors
Exclusive: Demand for blood to treat the rare disorder has soared by 132% in 10 years Demand for blood needed to treat rare disorders such as sickle cell has soared by more than…
Agios Seeks FDA Nod to Expand Mitapivat Label in Sickle Cell Disease
Agios Pharmaceuticals AGIO announced that it has submitted a supplemental new drug application (sNDA) to the FDA seeking accelerated approval for the label expansion of its lead…
26-Year-Old Man With Posttransfusion Hyperhemolysis
Severe posttransfusion hyperhemolysis in a sickle cell patient produced profound anemia and lactic acidosis; terminal complement blockade with eculizumab stabilized hemolysis and…
Govt Pledges Expanded Access to Sickle Cell Treatment Nationwide
The Permanent Secretary at Uganda’s Ministry of Health, Diana Atwine, has pledged increased access to sickle cell treatment and stronger prevention measures as African health…
Compound Heterozygous Sickle Cell-Beta Thalassemia Presenting As Chronic Hemolytic Anemia With Microcytosis and Prominent Left Ventricular Trabeculation: A Case Report
Abstract Sickle cell-beta thalassemia, a compound heterozygous hemoglobinopathy, can be difficult to diagnose because clinical features and laboratory findings often overlap with…
Integration of Sickle Cell Screening with Routine Immunization in Mbujimayi, a Remote City in the Democratic Republic of the Congo
Abstract Background: Sickle cell disease is the most common genetic disorder in the world. It is a real public health problem in sub-Saharan Africa. Early screening makes it…
Acute Chest Syndrome in Children with Sickle Cell Disease: A Narrative Review
Abstract Acute chest syndrome (ACS) is a common pulmonary complication in children with sickle cell disease, defined by a new pulmonary infiltrate on imaging accompanied by fever…