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Individuals with sickle cell disease (SCD) present at the emergency department (ED) and are often admitted for hospitalization most commonly for vaso-occlusive pain episodes (VOEs). These episodes also referred to as “pain crises” due to the intense pain experienced by patients, cause an acute arginine (Arg) deficiency.
Arg supplementation has shown positive impacts on blood pressure, and cardiopulmonary function, and has decreased the length of patient’s hospital stay. With supplementation, patients often require lower doses of opioids to manage the episode.
Previous research demonstrated intravenous (IV) Arg improves mitochondrial (Mito) function. Beyond this, not much is understood about the precise mechanisms that enable Arg to mediate such benefits in this patient population.
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This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.