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scientific articles

The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis

key information

source: Annals of Hematology

year: 2016

authors: Musa BM, Galadanci NA, Coker M, Bussell S, Aliyu MH

summary/abstract:

Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5-27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7–25.6) and 24.4 % (95 % CI 18.4-30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.

organisation: Bayero University/Aminu Kano Teaching Hospital; University of Maryland; Vanderbilt University School of Medicine, Nashville; Meharry Medical College, Nashville

DOI: 10.1007/s00277-016-2693-z

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