Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
How we manage iron overload in sickle cell patients
source: British Journal of Haematology
year: 2017
authors: Coates TD, Wood JC
summary/abstract:Blood transfusion plays a prominent role in the management of patients with sickle cell disease (SCD), but causes significant iron overload. As transfusions are used to treat the severe complications of SCD, it remains difficult to distinguish whether organ damage is a consequence of iron overload or is due to the complications treated by transfusion. Better management has resulted in increased survival, but prolonged exposure to iron puts SCD patients at greater risk for iron-related complications that should be treated. The success of chelation therapy is dominated by patient adherence to prescribed treatment; thus, adjustment of drug regimens to increase adherence to treatment is critical. This review will discuss the current biology of iron homeostasis in patients with SCD and how this informs our clinical approach to treatment. We will present the clinical approach to treatment of iron overload at our centre using serial assessment of organ iron by magnetic resonance imaging.
organization: Keck School of Medicine, University of Southern CaliforniaDOI: 10.1111/bjh.14575
read more full text
+myBinderRelated Content
-
Increasing Appointment Attendance: A Vital Opportunity to Improve Health Outcomes for Those Living with Sickle Cell ...Sickle cell disease (SCD) affects approx...
-
The effects of music therapy on transition outcomes in adolescents and young adults with sickle cell diseaseBackground: The Build, Educate, Advance...
-
Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical TrialObjective: To determine whether inhaled...
-
Sickle Cell Disease: Racism in the American Health Care SystemWednesday, June 28 1-4 pm EDT Massachu...
-
Sickle Cell Disease and Marrow/Stem Cell Donationhttps://www.youtube.com/watch?v=mstThQc7...
-
Siklos (hydroxyurea) now available through ProCare Pharmacy Care’s Siklos At Home programMedunik USA announced today that...
-
Patrick C. Hines, MD, PhDPatrick C. Hines, MD, PhD is an experien...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.