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reference materials

Hand Foot Syndrome in Sickle Cell Anemia

key information

source: Family Practice Notebook


Hand Foot Syndrome in Sickle Cell Anemia:
II. Epidemiology
Often the first vaso-Occlusion crisis finding in young children
Occurs in up to 50% of children with Sickle Cell Anemia by the age of 2 years
Rare over age 4 years old

III. Pathophysiology

A. Not to be confused with Hand Foot Syndrome that occurs with certain Chemotherapy agents in non-sickle disease

B. Occurs in Sickle Cell Anemia with vaso-Occlusion

C. Caused by infarction of Bone Marrow
1. Metacarpal or Metatarsal Bones and phalanges

IV. Symptoms
Painful swelling and tenderness of either the hand or foot
Digits may appear mildly erythematous

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