Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Sickle cell disease
source: The Lancet
year: 2017
authors: Ware RE, de Montalembert M, Tshilolo L, Abboud MR
summary/abstract:Sickle cell disease is a common and life-threatening haematological disorder that affects millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in small vessels, and this vaso-occlusion leads to distal tissue ischaemia and inflammation, with symptoms defining the acute painful sickle-cell crisis. Repeated sickling and ongoing haemolytic anaemia, even when subclinical, lead to parenchymal injury and chronic organ damage, causing substantial morbidity and early mortality. Currently available treatments are limited to transfusions and hydroxycarbamide, although stem cell transplantation might be a potentially curative therapy. Several new therapeutic options are in development, including gene therapy and gene editing. Recent advances include systematic universal screening for stroke risk, improved management of iron overload using oral chelators and non-invasive MRI measurements, and point-of-care diagnostic devices. Controversies include the role of haemolysis in sickle cell disease pathophysiology, optimal management of pregnancy, and strategies to prevent cerebrovascular disease.
organization: Cincinnati Children's Hospital Medical Center; Hopital Necker, LABEX GR-Ex, Paris; Centre Hospitalier Monkole, Kinshasa; American University of BeirutDOI: 10.1016/S0140-6736(17)30193-9
read more full text
+myBinderRelated Content
-
MARAC Statement: Crizanlizumab (Adakveo)July 7, 2023 - SCDAA’s Medical and Res...
-
MARAC Statement: Health Insurance Coverage for Hematopoietic Stem Cell Transplant for Sickle Cell Disease from HLA-m...Hematopoietic stem cell transplant for s...
-
Newborn screening for sickle cell disease in Europe: Recommendations from a Pan-European Consensus ConferenceSickle Cell Disease (SCD) is an increasi...
-
Increased prevalence of type 2 diabetes-related complications in combined type 2 diabetes and sickle cell traitObjective: The prevalence of type 2 dia...
-
How One Child’s Sickle Cell Mutation Helped Protect the World From MalariaThousands of years ago, a special child ...
-
Sickle Cell Disease Management & Complications: Sophie Lanzkron MD of Johns HopkinsStuck on sickle cell disease? We hammer ...
-
Ty Montgomery says he’s not worried about sickle cell traitThe symptoms that kept Ty Montgomery out...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
SomeBodyToTalkTo connects people affected by rare diseases with trusted resources, supportive communities, and opportunities to share their experiences.