Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Very Low Incidence of Clostridioides Difficile Infection in Pediatric Sickle Cell Disease Patients
source: Haematologica
year: 2020
authors: Philip Lee, Arpan A. Sinha, Vijaya L. Soma, Carlos Cruz, Tao Wang, Olga Aroniadis, Betsy C. Herold, Paul S. Frenette, David L. Goldman, and Deepa Manwani
summary/abstract:Despite advances in the survival of pediatric patients with sickle cell disease (SCD), affected individuals continue to experience progressive end-organ damage, recurrent painful vaso-occlusive episodes (VOEs) and a shortened lifespan, highlighting the need for additional therapies. Recent animal and human studies suggest that antibiotic exposure may actually ameliorate the severity of SCD by altering the gastrointestinal microbiome. Specifically, depletion of intestinal microbiota by administration of broad-spectrum antibiotics significantly reduces the number of circulating pro-inflammatory, aged neutrophils and improves inflammation-related organ damage or endotoxin-induced septic shock in mouse models of SCD.
Further, routine administration of penicillin propylaxis to SCD patients up to 5 years of age has also been associated with a reduced percentage and absolute number of aged neutrophils. A recent murine study showed the dependence of stress-induced VOEs and inflammation on the gut microbiota, mediated by aged neutrophil expansion. These observations suggest that in addition to infection prevention, there may be a role for extended antibiotic “prophylaxis” to reduce SCD severity by modulating the gut microbiome to decrease inflammation.
organization: The Children’s Hospital at Montefiore, USA; The University of Oklahoma Health Sciences Center, USA; The Albert Einstein College of Medicine, USA; Montefiore Medical Center, USADOI: 10.3324/haematol.2019.244582
read more
+myBinderRelated Content
-
The ‘Voice of Lagos’ is silent: Entertainer Tosyn Bucknor dies at 37Nigerians are paying tribute t...
-
Nitric Oxide, Phosphodiesterase Inhibitors and Soluble Guanylate Cyclase Stimulators as Candidate Treatments for Sic...Despite being described in the medical l...
-
Longitudinal Analysis of Patient Specific Predictors for Mortality in Sickle Cell DiseaseINTRODUCTION: White Blood Cell (WBC) cou...
-
Research Team Recognized for Organ-on-a-Chip DesignSCD is a group of genetic disorders that...
-
GBT expands sickle cell disease pipeline with worldwide licensing agreement for inclacumab for the treatment of vaso...Global Blood Therapeutics, Inc...
-
Dr. Doris Wethers, 91, on Front Lines against Sickle Cell, DiesDr. Doris L. Wethers, who broke racial b...
-
New Research Suggests SANGUINATE™ Reduces the Number of Sickled Red Blood Cells in Patients with Vaso-Occlusive Cr...SANGUINATE™, the only investigational ...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.