Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Very Low Incidence of Clostridioides Difficile Infection in Pediatric Sickle Cell Disease Patients
source: Haematologica
year: 2020
authors: Philip Lee, Arpan A. Sinha, Vijaya L. Soma, Carlos Cruz, Tao Wang, Olga Aroniadis, Betsy C. Herold, Paul S. Frenette, David L. Goldman, and Deepa Manwani
summary/abstract:Despite advances in the survival of pediatric patients with sickle cell disease (SCD), affected individuals continue to experience progressive end-organ damage, recurrent painful vaso-occlusive episodes (VOEs) and a shortened lifespan, highlighting the need for additional therapies. Recent animal and human studies suggest that antibiotic exposure may actually ameliorate the severity of SCD by altering the gastrointestinal microbiome. Specifically, depletion of intestinal microbiota by administration of broad-spectrum antibiotics significantly reduces the number of circulating pro-inflammatory, aged neutrophils and improves inflammation-related organ damage or endotoxin-induced septic shock in mouse models of SCD.
Further, routine administration of penicillin propylaxis to SCD patients up to 5 years of age has also been associated with a reduced percentage and absolute number of aged neutrophils. A recent murine study showed the dependence of stress-induced VOEs and inflammation on the gut microbiota, mediated by aged neutrophil expansion. These observations suggest that in addition to infection prevention, there may be a role for extended antibiotic “prophylaxis” to reduce SCD severity by modulating the gut microbiome to decrease inflammation.
organization: The Children’s Hospital at Montefiore, USA; The University of Oklahoma Health Sciences Center, USA; The Albert Einstein College of Medicine, USA; Montefiore Medical Center, USADOI: 10.3324/haematol.2019.244582
read more
Related Content
-
Building Capacity to Reduce Stroke in Children With Sickle Cell Anemia in the Dominican Republic: The SACRED TrialThe prevalence of sickle cell anemia (SC...
-
Presence of pain on three or more days of the week is associated with worse patient reported outcomes in adults with...While acute episodic pain is the hallmar...
-
Sickle Cell Disease: Treatments – PAINWeekhttps://www.youtube.com/watch?v=llqCdRNK...
-
Fighting Through Our Pain TV with Thomas J. Harrington MDhttps://www.youtube.com/watch?time_conti...
-
APS Scientific Meeting 2019The American Pain Society will hold its ...
-
When Cracking Down On Opioids Means Tougher Access For Sickle Cell PatientsMany people with sickle cell disease wil...
-
New treatment plan leads to better pain control for acute sickle cell crisisThere’s new hope for the 70,000 to 80,...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.