Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Ticagrelor Does not Impact Patient-Reported Pain in Young Adults With Sickle Cell Disease: A Multicentre, Randomised Phase IIb Study
source: British Journal of Haematology
year: 2019
authors: Kanter J, Abboud MR, Kaya B, Nduba V, Amilon C, Gottfridsson C, Rensfeldt M, Leonsson-Zachrisson M
summary/abstract:Ticagrelor is an antiplatelet agent for adults with coronary artery disease. The inhibition of platelet activation may decrease the frequency of vaso-occlusion crisis (VOC) in sickle cell disease (SCD). The HESTIA2 study (NCT02482298) randomised 87 adults with SCD (aged 18-30 years) 1:1:1 to twice-daily ticagrelor 10, 45 mg or placebo for 12 weeks. Numerical decreases from baseline in mean proportion of days with patient-reported pain (primary endpoint) were seen in all three groups, as well as in pain intensity and analgesic use, with no significant differences between placebo and ticagrelor treatment groups. Plasma ticagrelor concentrations and platelet inhibition increased with dose. Adverse events were distributed evenly across groups and two non-major bleeding events occurred per group. Ticagrelor was well tolerated with a low bleeding risk, but no effect on diary-reported pain was detected. Potential effects on frequency of VOCs will need to be evaluated in a larger and longer study.
organization: Medical University of South Carolina, USA; American University of Beirut Medical Centre, Lebanon, Barts Health NHS Trust, UK; Kenya Medical Research Institute, Kenya; IMED Biotech Unit, Sweden; AstraZeneca R&D, SwedenDOI: 10.1111/bjh.15646
read more
+myBinderRelated Content
-
Long-term opioids may not be best pain management option for all sickle cell patientsSmall study shows some on opioids report...
-
Sickle Cell Data Collection (SCDC) ProgramThe Sickle Cell Data Collection (SCDC) p...
-
The Opioid Drug Epidemic and Sickle Cell Disease: Guilt by AssociationIn 2008, for the first time in Centers f...
-
Webinar Series: Sickle Cell Science: Path to Progress – Sickle Cell Disease Care in the Emergency Department: ...To commemorate Sickle Cell Awareness Mon...
-
Yale New Haven HospitalMedical teams at Yale New Haven Hospital...
-
WHATZ DA COUNTWDC on SCT has dedicated his Organizatio...
-
Mary Hulihan, DrPHDr. Mary Hulihan is the Health Scientist...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
SomeBodyToTalkTo connects people affected by rare diseases with trusted resources, supportive communities, and opportunities to share their experiences.