Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Septic Arthritis in Sickle Cell Anemia
source: Family Practice Notebook
year: 2018
summary/abstract:Septic Arthritis in Sickle Cell Anemia:
II. Causes
Staphylococcus aureus (most common cause)
Streptococcus Pneumoniae
Salmonella
III. Labs
Synovial Fluid (obtain in all suspected cases)
1. Normal Synovial Fluid cell count in >50% of Septic Arthritis cases
2. Gram Stain Test Sensitivity is only 50% (high False Negative Rate)
3. Synovial Fluid is the gold standard for diagnosis
IV. Management
A. Obtain Synovial Fluid culture and start empiric antibiotics
B. Total antibiotic course: 6 weeks
C. Initial empiric management
1. Cephaloporin sensitive
a. Ceftriaxone 50-75 mg/kg up to 2 g/dose OR
b. Ceftriaxone 75-100 mg/kg in high S. Pneumoniae resistance regions
2. Cephalosporin resistance
a. Clindamycin 10-15 mg/kg/dose (preferred) OR
b. Vancomycin 15 mg/kg/dose (if systemic Sepsis or Clindamycin reactions)
+myBinderRelated Content
-
Sickle Cell Patients are Innocent Victims of the Opioid Epidemic: Samir K. Ballas, MDhttps://www.youtube.com/watch?v=BOhY_gJo...
-
Approach to the diagnosis and treatment of acute subarachnoid hemorrhage in a patient with sickle cell diseaseWe report a case of subarachnoid hemorrh...
-
Outcome of severe vaso occlusive crisis in sickle cell disease adults admitted to referral centers in Africa and Eur...Introduction: Vaso-Occlusive Crisis (VOC...
-
New Guidelines for Managing Sickle Cell Disease Presented at ACP Internal Medicine MeetingNew guidelines for therapeutic strategie...
-
Reproductive Issues for Women With Sickle Cell Diseasehttps://www.youtube.com/watch?v=4vo_BPBn...
-
Sickle Cell and Young Stroke SurvivorsSickle Cell & Young Stroke Survivors...
-
FDA Awards $2M to Phase 2 Trial of Vitamin D for Reducing Risk of SCD Respiratory ComplicationsThe U.S. Food and Drug Administration (F...
Don’t forget to join the oneSCDvoice community!
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.
