Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Hand Foot Syndrome in Sickle Cell Anemia
source: Family Practice Notebook
year: 2018
summary/abstract:Hand Foot Syndrome in Sickle Cell Anemia:
II. Epidemiology
Often the first vaso-Occlusion crisis finding in young children
Occurs in up to 50% of children with Sickle Cell Anemia by the age of 2 years
Rare over age 4 years old
III. Pathophysiology
A. Not to be confused with Hand Foot Syndrome that occurs with certain Chemotherapy agents in non-sickle disease
B. Occurs in Sickle Cell Anemia with vaso-Occlusion
C. Caused by infarction of Bone Marrow
1. Metacarpal or Metatarsal Bones and phalanges
IV. Symptoms
Painful swelling and tenderness of either the hand or foot
Digits may appear mildly erythematous
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