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First Ischemic Stroke in Sickle-Cell Disease: Are There Any Adult Specificities?

key information

source: Stroke

year: 2015

authors: Calvet D, Bernaudin F, Gueguen A, Hosseini H, Habibi A, Galactéros F, Bartolucci P

summary/abstract:

BACKGROUND AND PURPOSE:
There is little evidence about characteristics of ischemic stroke (IS) occurring in adults with sickle-cell disease (SCD). The objective of this study was to assess characteristics of first-ever IS in adults with SCD and to assess whether they differ from those occurring in child patients with SCD.
METHODS:
Adult and child individuals with SCD who had a first-ever IS were identified from cohorts of patients followed up in an adult and a child sickle cell referral center. Mechanisms of IS were determined by consensus meeting from all available explorations using the following predefined classification: Vasculopathy, cardioembolism, other defined cause, and undetermined. Treatment and stroke recurrences were recorded from prospective follow-up performed in the referral centers.
RESULTS:
Twenty-nine adults and 26 children had a first-ever IS; mean age (SD) was 7.1 (4.3) and 32.3 (11.6), respectively. With regard to IS mechanism, vasculopathy was less often the cause of IS in adults (12/29, 41%) than in children (24/26, 92%; P<0.001). Other causes of IS in adults were cardioembolism in 7, antiphospholipid syndrome in 1, toxic (cocaine) in 1, and undetermined in 8. Adults with SCD had a higher risk of recurrent stroke (23.1% [7.0-39.2] at 5 years) compared with children (1 recurrence only; P log rank=0.046) despite exchange-blood transfusion in patients with vasculopathy.
CONCLUSIONS:
First-ever IS occurring in adults with SCD has specificities that justify further studies conducted in adults with SCD to improve understanding and management.

organization: Université Paris-Descartes, DHU Neurovasc-Paris Sorbonne; Centre Hospitalier Intercommunal, Créteil; Fondation Ophtalmologique A. de Rothschild, Paris; Hôpital Henri-Mondor, UPEC, Créteil; Laboratoire d'Excellence Grex, Créteil

DOI: 10.1161/STROKEAHA.115.010153

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