Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Facts About Sickle Cell Disease
source: Novartis Pharmaceuticals Corporation
year: 2019
summary/abstract:Sickle Cell Disease Goes Beyond Red Blood Cells and, Early on, Progresses to a Chronic Vascular Disease Vaso-Occlusive Crises May Account for a Majority of the Burden of Sickle Cell Disease
• Sickle cell disease (SCD) is a genetic blood disorder arising from mutations in the hemoglobin gene
• Multicellular adhesion among endothelium and blood cells is a major driver of vaso-occlusion and vaso-occlusive crises (VOCs)
• The upregulation and expression of specific adhesion mediators, including selectins, drive multicellular adhesion clusters
• VOCs are the clinical hallmark of SCD and originate from ongoing, silent, vaso-occlusion
read more
Related Content
-
Georgia Universities Join NIH-funded National Study of Bone Marrow Transplant for SCDThe Medical College of Georgia (MCG) and...
-
Facebook Live: Stem Cells and Sickle Cell Diseasehttps://www.youtube.com/watch?v=IPzNx8i_...
-
Survival in Sickle Cell Disease: Data from a Well-Resourced, National Health System SettingBackground: In well-resourced countries,...
-
Brigham and Women’s Sickle Cell Disease ClinicEach person with sickle cell disease is ...
-
Blood transfusion for preventing primary and secondary stroke in people with sickle cell diseaseBackground:Sickle cell disease is one of...
-
Jazz’ Journey With Sickle Cellhttps://www.youtube.com/watch?v=OMC5wOyD...
-
Paulette E. Forbes, MPH, MS, APNMs. Paulette E. Forbes serves as an inpa...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.